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Ceftaroline fosamil, a phosphoramidate prodrug launched in 2011 for the treatment of bacterial skin infections and bacterial pneumonia, showed 50-fold enhancement of solubility relative to the parental drug, thus enabling formulation of a marketable injectable solution [123]

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ROS also regulates intracellular free Ca 2+ concentration, activates Ca 2+ /calmodulin-dependent myosin light chain kinase (MLCK) and promotes cytoskeletal reorganization, which induces changes in endothelial cell shape and increases vascular permeability (163)